OakLS

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OakLS

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  • Home
  • Our Services
  • Contact Us
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  • Our Services
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Proportionate Clinical Protocols

For Natural Health Product Enhancement

Design lean, fit-for-purpose studies that are powerful enough to upgrade or expand Natural Health Product (NHP) claims—without “drug-sized” budgets. 

What We Do

Claim Laddering & Evidence Mapping

Claim Laddering & Evidence Mapping

Claim Laddering & Evidence Mapping

Translate business goals into claim types (e.g., helps to, structure/function, risk-reduction) and map the minimum adequate evidence to substantiate each claim. 

Proportionate Study Designs

Claim Laddering & Evidence Mapping

Claim Laddering & Evidence Mapping

Pragmatic RCTs, crossover or n-of-1 series, add-on designs, use-as-directed studies, and observational/RWE approaches when appropriate. 

Endpoints that Matter

Claim Laddering & Evidence Mapping

Right-Sized Statistics

Validated PROs, functional outcomes, and practical biomarkers aligned to the intended label text and advertising standards. 

Right-Sized Statistics

Ethics & Regulatory Alignment

Right-Sized Statistics

Sample size tied to minimally important differences; simple analyses with pre-specified SAP to keep studies efficient and credible. 

Efficient Operations

Ethics & Regulatory Alignment

Ethics & Regulatory Alignment

Decentralized/remote elements, eConsent, ePRO, and streamlined monitoring for minimal-risk studies. 

Ethics & Regulatory Alignment

Ethics & Regulatory Alignment

Ethics & Regulatory Alignment

REB-ready protocols, informed consent, and evidence packages aligned to Canadian expectations for NHPs—positioned for label updates and promotional substantiation. 

Quality & Compliance

Quality & Compliance

Quality & Compliance

GCP-lite governance proportional to risk, with TMF/eTMF, data integrity, and PV/AE capture sized for self-care products.  

Deliverables

  • Claim strategy & evidence matrix 
  • Protocol + ICF + SAP (proportionate format)
  • Statistical justification & case report forms (lean set)
  • REB submission package & site toolkit
  • Study report and claim substantiation dossier (review ready)


Outcome: credible, defensible claims—at a cost and timeline that makes sense for self-care brands. 

Contact Us Now

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