OakLS

OakLSOakLSOakLS
Home
Our Services
Contact Us

OakLS

OakLSOakLSOakLS
Home
Our Services
Contact Us
More
  • Home
  • Our Services
  • Contact Us
  • Home
  • Our Services
  • Contact Us

Clinical Trial Support

How We Work

Outcomes You Can Expect

Outcomes You Can Expect

Right-sized engagements—from targeted advisories to full program ownership. 

Outcomes You Can Expect

Outcomes You Can Expect

Outcomes You Can Expect

Faster approvals, inspection-ready documentation, predictable timelines and spend, and partners who are accountable for delivery. 


Oak LS delivers end-to-end clinical and regulatory support tailored to Health Canada and global expectations—lean, accountable, inspection-ready. 

Regulatory Strategy & Pathway to Market

We map the optimal route from concept to approval, aligning protocol design, operations, and filings

Contact Us Now

Pathway Assessment & Classification

Pathway Assessment & Classification

Pathway Assessment & Classification

Drug (DIN/NDS/SNDS), biologic, device, combination, NHP, or RWE/post-market route; global alignment (FDA/EMA/UK). 

Protocol-to-Pathway Alignment

Pathway Assessment & Classification

Pathway Assessment & Classification

Endpoints, populations, comparators, and risk controls engineered to support target labels and access claims. 

Pre-Submission Engagement

Pathway Assessment & Classification

Pre-Submission Engagement

Health Canada pre-CTA meetings (and FDA pre-IND/EMA Scientific Advice); question packages, briefing books, and rehearsals. 

Health Canada Interface

Health Canada Interface

Pre-Submission Engagement

Strategy memos, meeting management, minutes, follow-ups, and regulator correspondence throughout review. 

REB/Ethics Strategy

Health Canada Interface

REB/Ethics Strategy

Centralized vs. local REB path, multisite coordination, consent architecture, advertising approvals, and continuing review plans. 

Submission Roadmap

Health Canada Interface

REB/Ethics Strategy

CTA → NOL & amendments → pivotal/confirmatory strategy → NDS/SNDS or DIN/NHP filings; global sequencing and reliance options.

Risk, Quality & Evidence Plan

Risk, Quality & Evidence Plan

Risk, Quality & Evidence Plan

Inspection readiness, PV/DSUR/ASR strategy, HEOR/PRO/real-world data linkages, and publication/registry commitments. 

Deliverables

Risk, Quality & Evidence Plan

Risk, Quality & Evidence Plan

Regulatory strategy brief, decision tree, evidence matrix, submission timeline & RACIQ (risks/assumptions/constraints/issues/ queries) log. 

Additional Services

Strategy, Protocols & Submissions

  • Protocol development (interventional, observational, RWE) grounded in scientific, ethical, and operational feasibility. 
  • Authoring & submissions for CTA/HC and global filings; NDS/SNDS, DIN/NHP, amendments, and query management. 

Health Canada & REB

  • Complete HC and REB packages (initial, amendments, safety notifications, renewals). 
  • Centralized/multi-site coordination; sponsor representation during reviews. 

Pharmacovigilance & Safety Reporting

  • SAE/SUSAR intake and case management, medical review, unblinding pathways. 
  • DSUR/ASR, signal management, safety governance. 

CRO & Vendor Sourcing/Management

  • RFI/RFP design, bid defense, due diligence. 
  • KPI/SLA set-up, oversight of labs, eCOA/EDC, IRT, PV, biostats, logistics. 

Quality, TMF & Inspection Readiness

  • QMS and SOPs, vendor audits, eTMF QC/health checks. 
  • Mock inspections (HC/FDA/EMA), readiness training and remediation.  

Ethics, Training & Compliance

  • ICH-GCP (E6 R3), privacy (PIPEDA/GDPR), role-based study training. 
  • Informed consent/ICF optimization and documentation control. 

Independent Committees

  • DSMB/CEC chartering, membership, meeting operations, recommendations tracking. 

Copyright © 2026 OakLS - All Rights Reserved.


Powered by

This website uses cookies.

We use cookies to analyze website traffic and optimize your website experience. By accepting our use of cookies, your data will be aggregated with all other user data.

Accept